Answer any four from the remaining
Answer all parts of any Question at one place.
Time: 3 Hrs. Max. Marks: 70
1. Explain the following:
a) Folding Problem
b) Motifs
c) UniGene
d) Positional Cloning
e) Identity and Similarity
f) Consensus
g) Hidden Markov Models
h) Local Alignment Vs Global Alignment
i) Phylogenetic Tree
j) Folding Problem
2. a) What is bioinformatics? Explain the importance of bioinformatics?
b) What are the application areas of different analys is methods?
3. a) Explain the structure of SWISS-PROT entries.
b) Why create secondary databases?
4. a) Explain GenBank.
b) What is the importance of specialized genomic resources?
5. What is GenBank? Explain the structure of GenBank entries
6. a) Explain Central Dogma of Molecular biology with neat diagram.
b) Describe features of DNA sequence analysis
7. a) Write about BLAST (Basic Local Alignment Search Tool)
b) Explain the Needleman and Wunsch algorithm for global alignment
8. a) Define Multiple sequence alignment? What is the goal of Multiple
sequence alignment?
b) Explain simultaneous methods and progressive methods for multiple
alignments?
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